Journal article
Decreased Circulating Very Small Low-Density Lipoprotein is Likely Causal for Age-Related Macular Degeneration
S Farashi, R Bonelli, VE Jackson, BRE Ansell, RH Guymer, M Bahlo
Ophthalmology Science | ELSEVIER | Published : 2024
Abstract
Objective: Abnormal changes in metabolite levels in serum or plasma have been highlighted in several studies in age-related macular degeneration (AMD), the leading cause of irreversible vision loss. Specific changes in lipid profiles are associated with an increased risk of AMD. Metabolites could thus be used to investigate AMD disease mechanisms or incorporated into AMD risk prediction models. However, whether particular metabolites causally affect the disease has yet to be established. Design: A 3-tiered analysis of blood metabolites in the United Kingdom (UK) Biobank cohort to identify metabolites that differ in AMD patients with evidence for a putatively causal role in AMD. Participants:..
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Grants
Awarded by Lowy Medical Research Institute
Funding Acknowledgements
This work was supported by a National Health and Medical Research Council (NHMRC) of Australia Synergy grant to MB and BREA, RG (GNT1181010) . BREA was supported by an NHMRC Early Career Fellowship (GNT1157776) and MB and RG are supported by an NHMRC Investigator Grant (GNT1195236, GNT1194667) . This work was also made possible through the Victorian State Government Operational Infrastructure Support and the NHMRC Independent Research Institute Infrastructure Support Scheme (IRIISS) .r This work was supported by a National Health and Medical Research Council (NHMRC) of Australia Synergy grant to MB and BREA, RG (GNT1181010) . BREA was supported by an NHMRC Early Career Fellowship (GNT1157776) and MB and RG are supported by an NHMRC Investigator Grant (GNT1195236, GNT1194667) . This work was also made possible through the Victorian State Government Operational Infra-structure Support and the NHMRC Independent Research Institute Infra-structure Support Scheme (IRIISS) .